watching your episodes of Hamilton's pharmacopoeia, I see this kind of bouncing back and forth and not just bouncing sort of integrating and sometimes tension between the episodes in the parts that focus on the modern-day scientists weather underground or operating above ground, but then in other episodes going and looking at traditional uses, whether it's Iboga in Gabon, whether it's something in Argentina, whether it's something in Mexico, or peyote, what have you. And I see, as I said before, some of the reverence I sometimes, see when you're talking to the kind of modern-day chemist, both, you know, illegal and legal. And then there's this kind of Rye. Look, you have when you're engaged in some of the more indigenous practices in particular, their great belief that the plant is somehow fundamentally. Only different, then the drug that it contains, and that can be easily synthesized in a laboratory and my reading you, right? There. Is
there something in particular that you're referring to, there's
part of this whole debate or discussion between the natural versus synthetic you. And I were both at this Horizons conference in New York in late 2021. And, you know, that's part of what goes are, you know, is there something fundamentally different between peyote and mescaline between psilocybin produced synthetically? Akley and mushrooms, the issue of 5 m e0 DMT and you're making the case, you know, like, let's save the toad, right? You. If all human beings descended on the to Sonoran Desert or Arizona, whatever, and, and destroy the total just people should shift to the synthetic and people are having very strong reactions against that. And then, I think maybe the other part of that is is some of your skepticism, sometimes about the role of the shaman. The Shaymin, what do you think? Yeah.
I mean, these are all very very Complicated issues that have to be assessed on a case-by-case basis because there are definitely instances where a single alkaloid does not effectively replicate the effect of a plant and there are other instances where it does, so it really depends on what you're talking about. In the case of bufo alvarius Venom. It's clear to me based on all published chemical analyses, that the only tryptamine Isn't in that Venom that could be responsible for the effect that people are describing is 5 m e0. DMT bufotenin is present, in Trace concentrations. And I say this as somebody who has actually used pure analytically confirmed bufotenin. It does not produce the sort of visionary experience that most people look for when they take a second out. Nobody talks about bufotenin. Nobody is saying, oh, I'll bufotenin. That's my favorite psychedelic. And the reason is that it's incredibly nauseating. It doesn't have the same Visionary characteristics of something like d. T or silicon or five Meo DMT. And so what people are interested in is a 5, m, EO, D, Mt. Mediated effect. Then at the same time, you have this massive demand for toad Venom, that will easily have catastrophic ecological consequences. If everybody starts doing this. And it's going to look bad and it's going to be unnecessary. And then you have this easy to synthesize chemical 5 Mod Mt. And in this instance, the choice is clear in other instances. It's a bit more complicated. Located, for example, in peyote. There are actually are other alkaloids that likely contribute to the psychopharmacology in a meaningful way. The same is true of iboga in the case of psilocybin containing mushrooms. It's actually closer to toad Venom again where people say, oh, but there's a study that found one, femto gram of some beta-carboline in a mushroom ones there for silicon or psilocybin. Could never replicate the mushroom experience. Well, I don't think that there's strong evidence that any of the other trip. Ins present in psilocybin containing mushrooms are major contributors. So this is like I said, it's just you have to look at it at a on a case-by-case basis
Natural vs. Synthetic Drugs Debates Must Be Examined Case By Case
Hamilton Morris on Pharmacological Creations, Myths & Heroes