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One very large likely contributor to all the important effects of multi-day fasting or fasting-mimicking are the changes that happen to a cell signaling pathway known as the growth hormone IGF-1 axis. The IGF-1 axis is an extremely important pathway that is activated potently when we consume essential amino acids and protein but is reduced by up to 50% after just a few days of fasting in
humans.
Valter Longo
Fasting Reduces IGF-1 Axis Activity, Enhancing Cellular Repair & Inhibiting Cancer Growth
Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD
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