When people are given a low dose of LPS... the individuals had up to a 100-fold increase in their inflammatory biomarkers. So, they had a 25-fold increase in TNF-alpha, a very powerful pro-inflammatory cytokine, and a 100-fold increase in IL-6, which is also a pro-inflammatory cytokine. They also had an increase in markers of insulin resistance... and markers of insulin sensitivity decreased by 21%.